Multimorbidity

People with mental illness are known to be at increased risk of a range of physical health conditions, at a younger age, and suffer worse outcomes related to these conditions. Comorbidity has been well studied in people with mental illness, and previous studies have found that people with mental illness have a higher number of physical health conditions than the general population. The challenges of the increased complexity of managing multiple physical health conditions may disproportionally affect those with mental illness, further increasing inequality in health outcomes and increasing both secondary mental health and acute service use. The concept of multimorbidity represents a shift from a single disease-centric approach to a more patient-centred view. Moving beyond disease pairs or counts of disease and studying the way in which diseases and risk factors cluster within individuals is crucial for improving patient outcomes through better diagnosis, treatment, and healthcare service provision.

Publications

Antidepressant treatment and mortality in people with comorbid depression and type 2 diabetes: UK electronic health record study.

Annie Jeffery, Kate Walters, Ian C K Wong, David Osborn, Joseph F Hayes

BJPsych Open, 2024

Exploring the co-occurrence of depression, anxiety and insomnia symptoms, diagnoses and treatments in primary care: observational study using UK primary care data.

Danielle Nimmons, J. C. Bazo-Alvarez, C. Avgerinou, Joseph Hayes, David Osborn, Claudia Cooper, I. Petersen, Kate Walters

BJPsych Open, 2024

Ethnic differences in depression and anxiety among adults with atopic eczema: Population‐based matched cohort studies within UK primary care

Elizabeth I Adesanya, Alasdair D. Henderson, Joseph F Hayes, Alexandra Lewin, R. Mathur, A. Mulick, Caroline Morton, Catherine Smith, Sinéad M Langan, Kathryn E Mansfield

Clinical and Translational Allergy, 2024

Common mental health disorders in adults with inflammatory skin conditions: nationwide population-based matched cohort studies in the UK

Alasdair D. Henderson, Elizabeth I Adesanya, A. Mulick, J. Matthewman, Nhung Vu, Firoza Davies, Catherine Smith, Joseph F Hayes, K. Mansfield, S. Langan

BMC Medicine, 2023

The association between antidepressant treatment and rates of insulin initiation in comorbid depression and type 2 diabetes: A UK electronic health record nested case-control study.

Annie Jeffery, Kate Walters, Ian C. K. Wong, David Osborn, Joseph F. Hayes

Diabetes Research and Clinical Practice, 2023

Vaccine effectiveness of BNT162b2 and CoronaVac against SARS-CoV-2 omicron infection and related hospital admission among people with substance use disorder in Hong Kong: a matched case-control study

Caige Huang, Yue Wei, Vincent K. C. Yan, Xuxiao Ye, Wei Kang, H. H. Yiu, J. Shami, B. Cowling, M. Tse, D. J. Castle, C. Chui, F. Lai, Xia Li, E. Wan, C. Wong, Joseph F Hayes, W. Chang, A. K. Chung, Chak S. Lau, I. Wong, E. Chan

Lancet psychiatry, 2023

Severe Mental Illness Among Adults with Atopic Eczema or Psoriasis: Population-Based Matched Cohort Studies within UK Primary Care

Elizabeth I Adesanya, Alasdair D Henderson, J. Matthewman, K. Bhate, Joseph F Hayes, A. Mulick, R. Mathur, Catherine Smith, H. Carreira, S. Rathod, S. Langan, K. Mansfield

Clinical Epidemiology, 2023

Anxiety and Depression in People with Eczema or Psoriasis: A Comparison of Associations in UK Biobank and Linked Primary Care Data

J. Matthewman, K. Mansfield, Joseph F Hayes, Elizabeth I Adesanya, Catherine Smith, A. Roberts, S. Langan, Alasdair D. Henderson

Clinical Epidemiology, 2023

Electronic screening for mental illness in patients with psoriasis

K. Bechman, Joseph F Hayes, Julian Mathewman, Alasdair D. Henderson, Elizabeth I Adesanya, K. Mansfield, Catherine H. Smith, J. Galloway, S. Langan

British Journal of Dermatology, 2023

Ethnic differences in the indirect effects of the COVID-19 pandemic on clinical monitoring and hospitalisations for non-COVID conditions in England: a population-based, observational cohort study using the OpenSAFELY platform

R. Costello, J. Tazare, D. Piehlmaier, E. Herrett, E. Parker, Bang Zheng, K. Mansfield, Alasdair D. Henderson, H. Carreira, P. Bidulka, A. Wong, C. Warren-Gash, Joseph F Hayes, J. Quint, B. Mackenna, A. Mehrkar, R. Eggo, S. Katikireddi, L. Tomlinson, S. Langan, R. Mathur, N. Chaturvedi, Chloe M. Park, Alisia Carnemolla, Dylan M. Williams, Anika Knueppel, A. Boyd, E. Turner, Katharine Evans, Richard Thomas, S. Berman, Stela McLachlan, Matthew A. Crane, Rebecca Whitehorn, Jacqui Oakley, Diane Foster, H. Woodward, Kirsteen Campbell, N. Timpson, A. Kwong, A. Soares, G. Griffith, Renin Toms, L. Jones, Herbert Annie, R. Mitchell, T. Palmer, J. Sterne, V. Walker, Lizzie Huntley, Laura Fox, R. Denholm, R. Knight, K. Northstone, Arun Kanagaratnam, E. Horne, H. Forbes, Teri-Louise North, K. Taylor, Marwa Al Arab, Scott Walker, José Ignacio Cuitún Coronado, Arun S. Karthikeyan, G. Ploubidis, B. Moltrecht, C. Booth, Sam Parsons, B. Wielgoszewska, Charis Bridger-Staatz, C. Steves, E. Thompson, Paz Garcia, N. Cheetham, R. Bowyer, Maxim B Freydin, A. Roberts, B. Goldacre, A. Walker, J. Morley, W. Hulme, L. Nab, Louis Fisher, Colm D Andrews, H. Curtis, L. Hopcroft, A. Green, P. Patalay, J. Maddock, Kishan Patel, J. Stafford, Wels Jacques, K. Tilling, J. Macleod, E. McElroy, A. Shah, R. Silverwood, S. Denaxas, Robin Flaig, D. McCartney, A. Campbell, L. Smeeth, T. Cowling, K. Mansfield, R. Costello, K. Wang, K. Mansfield, V. Mahalingasivam, I. Douglas, S. Langan, S. Brophy, Michael Parker, J. Kennedy, R. McEachan, J. Wright, K. Willan, Ellena Badrick, G. Santorelli, Tiffany C. Yang, B. Hou, A. Steptoe, D. Giorgio, Jingmin Zhu, P. Zaninotto, Angela Wood, G. Cézard, Samantha Ip, T. Bolton, Alexia Sampri, Elena Rafeti, Fatimah Almaghrabi, Aziz Sheikh, S. A. Shah, V. Katikireddi, Richard J. Shaw, O. Hamilton, Michael J Green, T. Kromydas, D. Kopasker, F. Greaves, Robert Willans, F. Glen, Steve Sharp, Alun D. Hughes, A. Wong, Lee Howes, A. Rapala, Lidia Nigrelli, Fintan McArdle, C. Beckford, B. Raman, R. Dobson, A. Folarin, C. Stewart, Y. Ranjan, J. Carpentieri, L. Sheard, Chao Fang, Sarah A Baz, A. Gibson, J. Kellas, S. Neubauer, S. Piechnik, E. Lukaschuk, L. Saunders, James M. Wild, Stephen Smith, P. Jezzard, E. Tunnicliffe, Zeena-Britt Sanders, L. Finnigan, V. Ferreira, Mark Green, R. Rhead, Milla Kibble, Yinghui Wei, A. Lemanska, F. Pérez-Reche, L. Teece, Edward Parker, A. Walker, P. Inglesby, H. Curtis, C. Morton, J. Morley, S. Bacon, G. Hickman, R. Croker, D. Evans, T. Ward, N. Devito, A. Green, J. Massey, Rebecca M. Smith, W. Hulme, S. Davy, Colm D Andrews, L. Hopcroft, H. Drysdale, I. Dillingham, R. Park, Rose Higgins, Christine Cunningham, Milan Wiedemann, S. Maude, O. Macdonald, B. Butler-Cole, Thomas O'Dwyer, C. Stables, Christopher Wood, A. D. Brown, V. Speed, L. Bridges, A. Schaffer, C. Walters, C. Rentsch, K. Bhaskaran, Anna Schultze, E. Williamson, H. Mcdonald, L. Tomlinson, K. Wing, R. Grieve, D. Grint, I. Douglas, S. Evans, Jemma L Walker, T. Cowling, E. Herrett, C. Bates, J. Cockburn, John Parry, F. Hester, S. Harper, S. O’Hanlon, A. Eavis, R. Jarvis, D. Avramov, P. Griffiths, A. Fowles, N. Parkes, Brian Nicholson, R. Perera, D. Harrison, K. Khunti, J. Sterne, J. Quint

EClinicalMedicine, 2023

Association between polypharmacy and depression relapse in individuals with comorbid depression and type 2 diabetes: a UK electronic health record study.

Annie Jeffery, C. Bhanu, K. Walters, I. Wong, D. Osborn, Joseph F Hayes

The British journal of psychiatry : the journal of mental science, 2022

Polypharmacy and Antidepressant Acceptability in Comorbid Depression and Type 2 Diabetes

Annie Jeffery, C. Bhanu, K. Walters, I. Wong, D. Osborn, Joseph F Hayes

British Journal of General Practice, 2022

Factors associated with depression, anxiety, and severe mental illness among adults with atopic eczema or psoriasis: a systematic review and meta-analysis

Elizabeth I Adesanya, Julian Matthewman, Yochai Schonmann, Joseph F Hayes, Alasdair D Henderson, R. Mathur, Amy R Mulick, Catherine H Smith, Sinéad M Langan, K. Mansfield

British Journal of Dermatology, 2022

Clustering of physical health multimorbidity in people with severe mental illness: An accumulated prevalence analysis of United Kingdom primary care data

N. Launders, Joseph F Hayes, Gabriele Price, D. Osborn

PLoS medicine, 2022

The incidence rate of planned and emergency physical health hospital admissions in people diagnosed with severe mental illness: a cohort study.

N. Launders, Joseph F Hayes, Gabriele Price, L. Marston, D. Osborn

Psychological medicine, 2022

The impact of comorbid severe mental illness and common chronic physical health conditions on hospitalisation: A systematic review and meta-analysis

N. Launders, Kate Dotsikas, L. Marston, Gabriele Price, D. Osborn, Joseph F Hayes

PloS one, 2022

Cancer rates and mortality in people with severe mental illness: Further evidence of lack of parity

N. Launders, Laura Scolamiero, D. Osborn, J. Hayes

Schizophrenia Research, 2022

The temporal relationship between severe mental illness diagnosis and chronic physical comorbidity: a UK primary care cohort study of disease burden over 10 years.

N. Launders, L. Kirsh, D. Osborn, Joseph F Hayes

The lancet. Psychiatry, 2022

Mortality-causing mechanisms and healthcare resource utilisation of treatment-resistant depression: A six-year population-based cohort study

Vivien KY Chan, Edmund CL Cheung, Sandra S. Chan, Martina Knapp, Joseph F Hayes, M. Fan, F. T. Lai, Hao Luo, T. Lum, Rosa SM Wong, Lauren KW Lau, Eric Y. F. Wan, G. Wong, E. Chan, P. Ip, I. Wong, Xia Li

The Lancet regional health. Western Pacific, 2022

Association between the pharmacological treatment of bipolar disorder and risk of traumatic injuries: a self-controlled case series study.

V. W. W. Ng, Le Gao, E. Chan, Ho Ming Edwin Lee, J. Hayes, D. Osborn, T. Rainer, K. Man, I. C. Wong

Psychological medicine, 2022

Incidence and associations of hospital delirium diagnoses in 85979 people with severe mental illness: a data linkage study.

Yehudit Bauernfreund, N. Launders, G. Favarato, Joseph F Hayes, D. Osborn, E. Sampson

Acta psychiatrica Scandinavica, 2022

Association of Long-Acting Injectable Antipsychotics and Oral Antipsychotics With Disease Relapse, Health Care Use, and Adverse Events Among People With Schizophrenia

Yue Wei, Vincent K. C. Yan, Wei Kang, I. Wong, D. J. Castle, Le Gao, C. Chui, K. Man, J. Hayes, W. Chang, E. Chan

JAMA network open, 2022

Prevalence and characteristics of antidepressant prescribing in adults with comorbid depression and type 2 diabetes mellitus: A systematic review and meta-analysis

A. Jeffery, Lucy Maconick, E. Francis, K. Walters, I. Wong, D. Osborn, J. Hayes

Health sciences review, 2021

Impact of the COVID‐19 pandemic on use of anti‐dementia medications in 34 European and North American countries

Chengsheng Ju, W. Lau, J. Hayes, D. Osborn, K. Man, E. Chan, I. Wong, Li Wei

Alzheimer's & dementia, 2021

Indirect acute effects of the COVID-19 pandemic on physical and mental health in the UK: a population-based study

K. Mansfield, R. Mathur, J. Tazare, Alasdair D Henderson, A. Mulick, H. Carreira, A. Matthews, P. Bidulka, A. Gayle, H. Forbes, Sarah Cook, A. Wong, H. Strongman, K. Wing, C. Warren-Gash, S. Cadogan, L. Smeeth, J. Hayes, J. Quint, M. Mckee, S. Langan

The Lancet. Digital health, 2021

Association Between Childhood Visual Acuity and Late Adolescent Psychotic Experiences: A Prospective Birth Cohort Study

Natalie Shoham, J. Hayes, C. Cooper, Magnus Theodorsson, G. Lewis

Schizophrenia bulletin, 2021

Associations between psychosis and visual acuity impairment: A systematic review and meta‐analysis

Natalie Shoham, Michelle Eskinazi, J. Hayes, G. Lewis, Magnus Theodorsson, C. Cooper

Acta psychiatrica Scandinavica, 2021

Clustering of physical health multimorbidity in 68,392 people with severe mental illness and matched comparators: a lifetime prevalence analysis of United Kingdom primary care data

N. Launders, J. Hayes, G. Price, D. Osborn

medRxiv, 2021

Risk factors for mental illness in adults with atopic eczema or psoriasis: protocol for a systematic review

Elizabeth I Adesanya, Y. Schonmann, Joseph F Hayes, R. Mathur, A. Mulick, L. Rayner, L. Smeeth, Catherine H. Smith, S. Langan, K. Mansfield